David K MenonName: David Krishna MENON MBBS, MD, PhD, FRCP, FRCA, FFICM, FMedSci
Appointments: Professor of Anaesthesia, University of Cambridge; Consultant in Neurocritical Care, Addenbrooke’s Hospital Cambridge
Address: Box 93, Addenbrooke’s Hospital, Cambridge CB2 2QQ, UK
Phone: +44 1223 217889/217891; Fax: +44 1223 217887/217223; email: This email address is being protected from spambots. You need JavaScript enabled to view it.


Research summary:

I obtained my PhD in 2006 from London University. I am a Principal Investigator in the Wolfson Brain Imaging Centre, and Co-Chair of the Acute Brain Injury Program at the University of Cambridge. I currently act as Vice-Coordinator of the CENTER-TBI project, a €30 million European multicentre study of precision medicine and comparative effectiveness research in TBI. My research interests include neurocritical care, secondary brain injury, neuroinflammation, and metabolic imaging of acute brain injury, using positron emission tomography and high field magnetic resonance imaging. Research in my group has been supported by funding from several sources, including the Academy of Medical Sciences, the Medical Research Council, the European Commission’s FP7 Program, the Royal College of Anaesthetists, the Evelyn Trust, and the Wellcome Foundation. My publications include the first in vivo demonstration of neuronal loss in clinical AIDS; the first fMRI study of drug effects on regional cerebral blood flow; the first use of functional imaging to document cognitive processing in the persistent vegetative state; demonstration of the impact of specialist neurocritical care on outcome in head injury; the first conclusive demonstration of regional ischaemia in head injury.; the first documentation of diffusion barrier hypoxia as a pathophysiological mechanism in TBI; the current international definition of TBI; and the first validated use of [11C]PIB PET to image amyloid deposition in traumatic brain injury.


Current grant funding:

2011-2014
EU Framework 7: TBIcare (European multinational study; DKM is UK-PI) € 4,245,377

2011-2014
MRC.Interrogating energy metabolism in human brain using 13C microdialysis and magnetic resonance spectroscopy (CoI) £475,000

2011-2014
MRC. Investigation of the role of brain amyloid in cognition, brain atrophy and Alzheimer,s disease in Down’s syndrome (CoI)£936,049

2011-2016
Canadian Institutes of Health Research Canadian. Sleep and circadian rhythms in moderate and severe traumatic brain injury. (Co-I) Canadian $682,730

2012-2015
Role of HCN ion channels in neuropathic pain: a combinedanimal and human study (Co-I)
£ 793,051

2012-2015
MICA: A comprehensive genomic and functional approach to discover new ion channel targets  (Co-I) £1,238,290

2014-2017
National Institute for Health Research: NIHR Senior Investigator Award (Renewal – PI)
£ 45,000

2013-2020
FP7 Program: Collaborative European NeuroTrauma Effectiveness Research in TBI: CENTER-TBI (Co-PI) €30,000,000


Recent publications (h-index: 50)

1. Coles JP, Cunningham AS, Salvador R, Chatfield DA, Carpenter A, Pickard JD, Menon DK. Early metabolic characteristics of lesion and nonlesion tissue after head injury. J Cereb Blood Flow Metab 2009; 29(5):965-75.

2. Janowitz T, Menon DK. Exploring new routes for neuroprotective drug development in traumatic brain injury. Sci Transl Med 2010;2(27):27rv1.

3. Newcombe VF, Williams GB, Outtrim JG, Chatfield D, Gulia Abate M, Geeraerts T, Manktelow A, Room H, Mariappen L, Hutchinson PJ, Coles JP, Menon DK. Microstructural basis of contusion expansion in traumatic brain injury: insights from diffusion tensor imaging. J Cereb Blood Flow Metab 2013; 33(6):855-62.

4. Young YT, Veenith T, Dewar D, Outtrim JG, Mani V, Williams C, Pimlott S, Hutchinson PJA, Tavares A, Canales R, Mathis CA, Klunk WE, Aigbirhio FI, Coles JP, Baron J-C, Pickard JD, Fryer TD, Stewart W, Menon DK. Amyloid Imaging With Carbon 11–Labeled 3 Pittsburgh Compound B for Traumatic Brain. JAMA Neurology 2014; 71(1):23-31.

5. Helmy A, Guilfoyle MR, Carpenter KLH, Pickard JD, Menon DK, Hutchinson PJ. Recombinant human interleukin-1 receptor antagonist in severe traumatic brain injury: a Phase II randomised control trial. J Cereb Blood Flow Metab. 2014 (Epub ahead of print) doi:10.1038/jcbfm.2014.23, PMID 24569690.

 

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